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KMID : 0386319840170010105
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Korean Leprosy Bulletin
1984 Volume.17 No. 1 p.105 ~ p.110
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Immunotherapy Using a Mixture of Heat-Killed M. Leprae and Live BCG for Active Lepromatous Leprosy Patients
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Abstract
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Eleven patients with active lepromatous leprosy were observed before and after
immunotherapy with a mixture of heat-killed M. leprae and live BCG has been given
once in two months. The vaccine we use contains 1×108 bacilli of M.
leprae from nodules of lepromatous Patients and killed in the autoclave at 120℃ during
15 minutes, Plus viable BCG in a 0.02mg dose, the vaccine is applied intradermally in 2
sites at deltoid regions, After three or four times immunotherapy with this mixture, the
following results were obtained.
1) Appearance of reversal reaction was observed in 6 of 11 trial cases after
immunotherapy and rapid clinical improvement is expected.
2) The decrease of Bacterial Index by skin scraping examination was not shown in 10
cases: however one case showed 1+BI decrease.
3) 10 cases (91%) has shown positive conversion of Fernandez reaction after
immunotherapy and 4 cases (36.4%) shown positive conversion of Mitzuda reaction.
4) The injections were well tolerated, but small ulcer developed at injection sites in
many case
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KEYWORD
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